Blocking Adenosine/A2AR Pathway for Cancer Therapy

Adenosine is a metabolite produced abundantly in the tumor microenvironment, dampening immune response in inflamed tissues via adenosine A2A receptor (A2AR) which is widely expressed on immune cells, inhibiting anti-tumor immune response accordingly.Therefore, blocking adenosine signaling pathway is Bags of potential to promote anti-tumor immunity.

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Metabolic reprogramming and crosstalk of cancer-related fibroblasts and immune cells in the tumor microenvironment

It is notorious that cancer cells alter their metabolism to adjust to harsh environments of hypoxia and nutritional starvation.Metabolic reprogramming most often occurs in the tumor microenvironment (TME).TME is defined as the cellular environment in which the tumor resides.This includes surrounding blood vessels, fibroblasts, immune cells, signali

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